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AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Tumor Necrosis Factor-related apoptosis-inducing ligand Receptor 2 (TRAIL R2) IgG fraction polyclonal antibody

Catalog NumberPCA-2137a-9
Product IdPCA-2137a-9
Product NameRabbit anti-Human Tumor Necrosis Factor-related apoptosis-inducing ligand Receptor 2 (TRAIL R2) IgG fraction polyclonal antibody
Temperature-20°C
Unit1mg
Price425
AvailabilityAvailable
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (LGERLAKQKIEDHLLSSGK) corresponding to amino acids 409-427 of human TRAIL R2. The IgG fraction was purified using Protein G-Sepharose.
IsotypeN/A
Mol WeightN/A
PurityN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA and Western blot (1:500 dilution) using the immunizing peptide. Tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL R2 or TRICK 2) or also termed death receptor 5 (DR5) is a type I membrane protein that contains a cytoplasmic death domain. It binds TRAIL and mediates apoptosis via intracellular adaptor molecule FADD/MORT 1 and activation of NF?B.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesSchneider, P. et al. (1997) FEBS Lett. 416, 329-334. Walczak, H. et al. (1997) EMBO J. 16, 5386-5397. Suliman, A. et al. (2001) Oncogene 20, 2122-2133. Falschlehner, C. et al. (2007) Int. J. Biochem. Cell Biol. 39, 1462-1475.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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