AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) IgG fraction polyclonal antibody

Catalog NumberPCA-2135a-9
Product IdPCA-2135a-9
Product NameRabbit anti-Human Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) IgG fraction polyclonal antibody
Temperature-20°C
Unit1mg
Price270
AvailabilityAvailable
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (VLIVIFTVLLQSLCVAVTY) corresponding to amino acids 17-35 of human TRAIL. The IgG fraction was purified using Protein G-Sepharose.
IsotypeN/A
Mol WeightN/A
PurityN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA and Western blot (1:100 dilution) using the immunizing peptide. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or Apo-2 ligand is a cytokine that belongs to TNF family and induces apoptosis of tumor cells by binding to its receptors, TRAIL R1 (DR4) and TRAIL R2 (DR5). Both Receptors contain death domains and two decoy receptors TRAIL-R3 (DcR1) and TRAIL-R4 (DcR2) that inhibit TRAIL function. TRAIL induces apoptosis and NF?B activation in many tissues and cells.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesWiley, S.R. et al. (1995) Immunity 3, 673-682, Pitti, R.M. et al. (1996) J. Biol. Chem. 271, 12687-12690. Wang, S. & El-Deiry, W.S. et al. (2003) Oncogene 22, 8628-8633.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.


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