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AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human C-erbB-2 IgG fraction polyclonal antibody

Catalog NumberPCA-2100a-9
Product IdPCA-2100a-9
Product NameRabbit anti-Human C-erbB-2 IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (AENPEYLGLDVPV) corresponding to amino acids 1243-1255 of human c-erbB-2/HER-2/neu oncoprotein. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody can be used in ELISA (1: 100 dilution), immunocytochemistry (1: 100 dilution) and it recognizes c-erbB-2 protein (185 kDa) in Western Blot of HeLa cell lysate (1: 500 dilution). C-erbB-2 oncoprotein is a 185 kDa type I membrane tyrosine kinase receptor and belongs to the EGF receptor family. It plays an important role in the control of intracellular signaling events which are crucial for cell growth, differentiation and survival. The overexpression of the erbB-2 proto-oncogene is associated with an aggressive human adenocarcinomas, mainly breast and ovarian tumours.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesSlamon, D.J. et al. (1989) Science 244 (4905), 707-712. Klapper, L.N. et al. (2000) Adv. Cancer Res. 77, 25-79.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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