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AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human B-cell Leukaemia/lymphoma 2 (Bcl-2) IgG fraction polyclonal antibody

Catalog NumberPCA-2070a-9
Product IdPCA-2070a-9
Product NameRabbit anti-Human B-cell Leukaemia/lymphoma 2 (Bcl-2) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (GAAPAPGIFSSQPG) corresponding to amino acids 41 - 54 of human Bcl-2. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA using the immunizing peptide and it recognizes a 25 kDa protein in Western Blot of extract from Jurkat cells. Bcl-2 is a protein localized on the mitochondrial outer membrane, endoplasmic reticulum, and nuclear envelope. It supresses apoptosis modulated by homodimerization or association with Bax and Bad, two cell death promoters. It may contribute to tumorigenesis by prolonging cell survival and by mutations in the Bcl-2 gene.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesReed, J.C. (1997) Nature 387, 773 - 776. Chan, S.L. & Yu, V.C. (2004) Clin. Exp. Pharmacol. Physiol. 31, 119 - 128. Sorenson, C.M. (2004) Biochim. Biophys. Acta 1644, 169 - 177. Kirkin, V. et al. (2004) Biochim. Biophys. Acta 1644, 229 - 249.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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