AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Cullin7 (CUL 7) IgG fraction polyclonal antibody

Catalog NumberPCA-2030a-9
Product IdPCA-2030a-9
Product NameRabbit anti-Human Cullin7 (CUL 7) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (RGVPYASCTATQSFSTF) corresponding to amino acids 1681-1697 of human Cullin 7. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA (1: 100 dilution) and Western blot (1: 1,000 dilution) using the immunizing peptide. Cullins (1, 2, 3, 4a, 5 and 7) are a family of proteins that assemble a large number of ubiquitin ligases to catalyse polyubiquitiation, as well as binding to various specific factors to recruit substrates. Cullin 7 (CUL 7) is a component of SCF-like E3 ubiquitin ligase complex and may play a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is a new oncogene that cooperates with Myc in transformation by blocking Myc-induced apoptosis in a p53-dependent manner.
FormulationSolution at 0.5 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesDias, D.C. et al. (2002) Proc. Natl. Acad. Sci. USA 99, 16601-16606. Kasper, J.S. et al. (2006) Biochem. Biophys. Res. Commun. 348, 132-138. Kim, S.S. et al. (2007) Cancer Res. 67, 9616-9622.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

top | home