AUSTRAL Biologicals Catalog

Product Sheet: Anti-Dimethylated human Tumor Suppresor p53 IgG fraction (monoclonal)

Catalog NumberTM-1801Z-55
Product IdTM-1801Z-55
Product NameAnti-Dimethylated human Tumor Suppresor p53 IgG fraction (monoclonal)
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 2D12/E8) obtained by immunization of mice with a KLH-conjugated synthetic peptide SHLKS [dimethyl-K]KGQST corresponding to aa367 – aa377 of human tumor suppressor p53. The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing
Biological ActivityThis antibody can be used in ELISA assays (1: 1,000 dilution). It recognizes dimethylated p53 (K372). p53 is a transcription factor that is mutated in approximately half of all human cancers. It controls the cell cycle, apoptosis and DNA repair in response to cytotoxic stresses. The C terminus of p53 is rich in lysines, which are subjected to different modifications to regulate p53 activity
FormulationSolution at 1.0 mg/mL in PBS
ReferencesChuikov, S. et .al. (2004) Nature 432, 353 – 360 ; Hupp, T.R. et. al. (1992) Cell 71, 875 – 886 ; Malkin, D. et. al. (1990) Science 250, 1233 – 1238.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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