AUSTRAL Biologicals Catalog

Product Sheet: Anti-human Tri-Methyl K20 Histone H4 (TRI-Methylated H4 K20) IgG fraction(monoclonal)

Catalog NumberTM-1501Z-55
Product IdTM-1501Z-55
Product NameAnti-human Tri-Methyl K20 Histone H4 (TRI-Methylated H4 K20) IgG fraction(monoclonal)
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 2F1/H7) obtained by immunization of mice with a KLH-conjugated synthetic peptide RHR[trimethyl-K]VLRDNIQG-C corresponding to aa17 – aa28 of human histone H4. The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing
Biological ActivityThis antibody can be used in ELISA assays (1: 1,000 dilution). It recognizes trimethylated H4 K20. The methylation of specific histone lysines controls the transcriptional regulation, in addition to the propagation of bulk chromosome structure and stability. Methylated histone H4 K20 is also involved in transcriptional silencing of human polycomb target genes and an important component of a repressive pathway that can index pericentric heterochromatin.
FormulationSolution at 0.5 mg/mL in PBS
ReferencesHampsey, M & Reinberg, D. (2003) Cell 113, 429; Schotta, G. et. al. (2004) Genes & Dev. 18, 1251 – 1262; Sims, R. J. et. al. (2003) Trends Genet. 19, 629 – 639.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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