AUSTRAL Biologicals Catalog

Product Sheet: Anti-human Di-Methyl K9 Histone H3 (DI-Methylated H3 K9) IgG fraction(monoclonal)

Catalog NumberTM-1421Z-55
Product IdTM-1421Z-55
Product NameAnti-human Di-Methyl K9 Histone H3 (DI-Methylated H3 K9) IgG fraction(monoclonal)
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 4H6/A10) obtained by immunization of mice with a KLH-conjugated synthetic peptide KQTAR[dimethyl-K]STGGK-C corresponding to aa4 – aa14 of human histone H3. The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing
Biological ActivityThis antibody can be used in ELISA assays (1: 1,000 dilution). It recognizes dimethylated H3 K9. The methylation of specific histone lysines controls aspects of short- and long-term transcriptional regulation, in addition to the propagation of bulk chromosome structure and stability. Methylated histone H3 K9 is also involved in transcriptional silencing of human polycomb target genes and epigenetic imprints of the inactive X-chromosome . Methylated H3 K9 is considered a mark of repressive chromatin state
FormulationSolution at 0.5 mg/mL in PBS
ReferencesSchotta, G. et. al. (2004) Genes & Dev. 18, 1251 – 1262 ; Rougeulle, C. et al. (2004) Mol. Cell. Biol. 24, 5475 – 5484; Sims, R. J. et. al. (2003) Trends Genet. 19, 629 – 639; Hampsey, M & Reinberg, D. (2003) Cell 113, 429 – 432.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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