AUSTRAL Biologicals Catalog

Product Sheet: Anti-human Suppressor of RNA Polymerase B (SRB7) IgG fraction(monoclonal)

Catalog NumberTM-1201X-55
Product IdTM-1201X-55
Product NameAnti-human Suppressor of RNA Polymerase B (SRB7) IgG fraction(monoclonal)
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 5F10/D11) obtained by immunization of mice with a recombinant human SRB7 (15 kDa). The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing
Biological ActivityThis antibody can be used in ELISA assays (1: 8,000 dilution) and Western blot (1: 8,000 dilution)). It recognizes human SRB7, an essential component of SRB7/MED-containing cofactor complex (SMCC). This complex associates with the RNA polymerase II holoenzyme through SRB7 to enhance the gene-specific activation or repression induced by DNA-binding transcription factors.
FormulationSolution at 0.5 mg/mL in PBS
ReferencesMyers, L.C. & Kornberg, R. D. (2000) Annu. Rev. Biochem. 69, 729 – 749 ; Gu, W. et. al. (1999) Mol. Cell 3, 97 – 108 ; Sun, X. et. al. (1998) Mol. Cell 2, 213 – 222; Maldonado, E. et. Al. (1996) Nature 381, 86 – 89.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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