AUSTRAL Biologicals Catalog

Product Sheet: Anti-human Histone Binding Protein or Retinoblastoma Binding Protein p46 (RBA p46) IgG fraction (monoclonal)

Catalog NumberTM-1101Y-55
Product IdTM-1101Y-55
Product NameAnti-human Histone Binding Protein or Retinoblastoma Binding Protein p46 (RBA p46) IgG fraction (monoclonal)
Temperature-20°C
Unit150µg
Price245
AvailabilityAvailable
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 7F2/F3) obtained by immunization of mice with histone binding protein p46 (46 kDa). The IgG fraction was purified using Protein G-Sepharose.
IsotypeIgG2a
PurityN/A
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing
Biological ActivityThis antibody can be used in ELISA assays (1: 4,000 dilution) and Western blot. It recognizes RbAp46, a nuclear histone-targeting subunit that target the NuRD (nucleosome remodeling histone deacetylase complex) and SIN3 complex (paired amphipathic helix domains) to their histone substrates regulated by nucleosomal DNA. NuRD is postulated to help maintain genes in a specific repressed state and SIN3 is involved in transcriptional repression. Both complexes also have specific functions in development
FormulationSolution at 1.0 mg/mL in PBS
ReferencesLoyola, A. & Almouzni, G. (2004) Biochim. Biophys. Acta 1677, 3 – 11 ; Philpott, A. et. al. (2000) Semin. Cell Dev. Biol. 11, 7 – 14; Ahringer, J. (2000) Trends Genet. 16, 351 – 356.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.


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